3 edition of Studies on the regulation of two Epstein-Barr virus latent promoters found in the catalog.
Studies on the regulation of two Epstein-Barr virus latent promoters
Written in English
|Statement||by David Ghosh.|
|LC Classifications||Microfilm 89/2209 (Q)|
|The Physical Object|
|Pagination||v, 87 leaves.|
|Number of Pages||87|
|LC Control Number||89892209|
The discovery of Epstein-Barr virus (EBV) by Epstein, Achong, and Barr, reported in (Lancet ), was stimulated by Denis Burkitt's rec- nition of a novel African childhood lymphoma and his postulation that an infectious agent was involved in the tumor's etiology (Nature, ). Since then, molecular and cellular biological and computational . Epstein-Barr Virus (EBV) causes infectious mononucleosis in normal adolescents and malignant B lymphocyte proliferation in immune compromised patients, in marmosets, or upon transfer of infected human B lymphocytes into SCID mice. EBV is also etiologically associated with African Burkitt's lymphoma, Hodgkin's Disease, and nasopharyngeal by: 8.
The latent membrane protein (LMP1) of Epstein–Barr virus (EBV) is expressed in EBV-associated nasopharyngeal carcinoma, which is notoriously metastatic. Although it is established that LMP1 re-presses E-cadherin expression and enhances the invasive ability of carcinoma cells, the mechanism underlying this repression remains to be by: Additionally, recent studies have shown that LANA is capable of activating cellular promoters. Therefore, we investigated whether LANA can affect transcription from two major EBV latent promoters. In this study, we demonstrated that LANA can efficiently transactivate both the LMP1 and C promoters in the human B-cell line BJAB as well as in the.
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc. Natl Acad. Sci. USA 99 Author: Kim Kd, Tanizawa H, De Leo A, Vladimirova O, Kossenkov A, Lu F, Showe Lc, Noma Ki, Lieberman Pm. Latent membrane protein 1 (LMP 1) is one of two Epstein-Barr virus (EBV)-encoded proteins that expressed in nasopharyngeal carcinoma (NPC) cells. Previous studies showed that a kb transcript of the LMP 1 gene, in addition to the kb transcript, was detected in a BEBV-containing, nude mice-passaged NPC tumor, CCited by:
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Understanding regulation of the EBV latent-lytic switch in epithelial cells has been hampered by lack of non-transformed epithelial cell lines that can be latently infected with EBV.
EBV does not efficiently infect normal undifferentiated epithelial cells .Cited by: Histone modifications may also contribute to the regulation of latent EBV promoters because the active Cp, Qp and LMP2Ap promoters that are marked by strong binding of cellular regulatory proteins are located on “acetylation islands” enriched in diacetylated histone H3 and tetraacetylated histone by: Epstein–Barr virus (EBV) infection contributes to the development of several different types of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma.
As a herpesvirus, EBV can establish latent or lytic infection in cells. EBV-positive tumors are composed almost exclusively of cells with latent EBV by: Studies of Epstein-Barr Virus Miller, I.
George Yale University, New Haven, CT, United States the two promoters that control BZLF1 transcription, are coordinately or sequentially regulated. Clues to the relative importance of cellular or viral factors in BZLF1 regulation should come from study of well characterized EBV transformed cell.
The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging Yi Guan 1, Dejan Jakimovski 1, Murali Ramanathan 2, Bianca Weinstock-Guttman 3, Robert Zivadinov MD, PhD, FAAN, FEAN, FANA 4 1 Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Cited by: Like all other herpesviruses, the oncogenic human gammaherpesvirus, Epstein-Barr virus (EBV; human herpesvirus 4) manifests two distinct phases in its life cycle: latency and lytic by: Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man.
It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), Price: $ Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many human disorders.
The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell by: Epstein-Barr Virus Nuclear Antigen Family 3 in Regulation of Cellular Processes Karen Sims, Abhik Saha, and Erle S.
Robertson Epstein-Barr virus (EBV) infects over 90% of the world's population, and like other herpesviruses it establishes a permanent latent infection in the host (Rickinson and Kieff, ). Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans.
To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that microRNAs (miRNAs) are powerful regulators of the maintenance of cellular Cited by: Chronic active Epstein-Barr virus infection (CAEBV) has been considered to be a non-neoplastic T-cell lymphoproliferative disease associated with Epstein-Barr virus (EBV.
The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive Qian Tao, Keith D.
Robertson, Angela Manns, Allan Hildesheim, Richard F. Ambinder Research output: Contribution to journal › ArticleCited by: The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive. Qian Tao, Keith D.
Robertson, Angela Manns, To characterize the role of CpG methylation in the regulation of the constitutively active Qp, we performed bisulfite genomic sequencing and functional analyses using a methylation Cited by: Epstein–Barr virus, a human gammaherpesvirus, possesses a unique set of latent genes whose constitutive expression in B cells leads to cell growth transformation.
The initiation of this growth transforming infection depends on a viral promoter in BamHI W (Wp) whose regulation is File Size: 2MB. Previous studies suggest that the Epstein-Barr virus nuclear antigen EBNA2 participates in the regulation of the expression of the viral latent membrane protein (LMP).
Tao Q, Robertson KD, Manns A, et al: The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive.
J Virol, Medline, Google Scholar: Tao Q, Robertson KD, Manns A, et al: Epstein-Barr virus (EBV) in endemic Burkitt’s lymphoma: Molecular analysis of primary tumor Cited by: Epstein–Barr virus and virus human protein interaction maps Michael A. Calderwood*, in latent B lymphocyte infection, lymphoproliferative disease, Burkitt lymphoma, Hodgkin disease, and nasopharyngeal car-cinoma.
The function of other EBV-specific and most gamma-Cited by: Chronic active Epstein–Barr virus infection (CAEBV) has been considered to be a non-neoplastic T-cell lymphoproliferative disease associated with Epstein–Barr virus (EBV) infection. In EBV-associated diseases, the cell phenotype-dependent differences in EBV latent gene expression may reflect the strategy of the virus in relation to latent by: The Epstein–Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.
It is best known as the cause of infectious mononucleosis ("mono" or "glandular fever"). It is also associated with various non-malignant, premalignant, and malignant Epstein–Barr virus Class: incertae sedis.
Studies on Immune Regulation of Epstein-Barr Virus Karen A. McAulay Doctor of Philosophy ii frequency of two TNF promoter alleles was significantly increased in PTLD Latent and lytic Epstein Barr virus (EBV) gene PCR.
The viral latent membrane protein 2A (LMP2A) has been shown to increase the invasive ability and induce epithelial–mesenchymal transition in nasopharyngeal carcinoma. Our present study reveals that mitochondrial dynamics also plays a critical role in Epstein–Barr virus-associated epithelial by: The unique feature of NPC is its strong association with Epstein–Barr virus (EBV) infection 1, 2.
Among the EBV‐encoded gene products expressed in NPC, latent membrane protein 1 (LMP1) is of particular interest, as it shows oncogenic properties in vitro and in vivo.
LMP1 is an integral membrane protein containing two signaling domains Cited by: Induction of Id1 and Id3 by latent membrane protein 1 of Epstein–Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol ;